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Vol. 32, No. 8(2), S&M2292

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Sensors and Materials
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Sensors and Materials, Volume 31, Number 10(1) (2019)
Copyright(C) MYU K.K.
pp. 3055-3066
S&M1992 Research Paper
https://doi.org/10.18494/SAM.2019.2495
Published: October 18, 2019

Distinguishing Mass Loading Effect from Damping Loading Effect of Piezoelectric Immunosensor Using Energy Transfer Model [PDF]

Yan Chen, Feng Tan, and Wen Cao

(Received June 30, 2019; Accepted September 12, 2019)

Keywords: piezoelectric (PZ) immunosensor, energy transfer model (ETM), mass loading effect, damping loading effect, NuTu-19 IgG

For a piezoelectric (PZ) immunosensor operating under damping loading conditions, the mass loading and damping loading effects cannot be distinguished by frequency measurement alone. In this work, a special relationship between the vibrational amplitude on the surface of a quartz crystal and the viscosity and density product of the tested liquid is derived using the energy transfer model (ETM). To detect the NuTu-19 antibody concentration in immune serum, we simultaneously measure the resonant frequency and rectified load voltage of the PZ immunosensor. Excellent agreement is obtained between the ETM-calculated value and the actual value obtained by the Bradford method. The experimental results proved the correctness of the deduced equation and showed that the presented analytical method laid a foundation for further development of all types of quartz crystal sensors in the liquid phase.

Corresponding author: Yan Chen


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Cite this article
Yan Chen, Feng Tan, and Wen Cao, Distinguishing Mass Loading Effect from Damping Loading Effect of Piezoelectric Immunosensor Using Energy Transfer Model, Sens. Mater., Vol. 31, No. 10, 2019, p. 3055-3066.



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